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Generic Digiter - Digoxin binds to a site on the extracellular aspect of the a-subunit of the Na+/K+ ATPase pump in the membranes of heart cells (myocytes). This causes an increase in the level of sodium ions in the myocytes, which then leads to a rise in the level of calcium ions. The proposed mechanism is the following: inhibition of the Na+/K+ pump leads to increased Na+ levels, which in turn slows down the extrusion of Ca2+ via the Na+/Ca2+ exchange pump. Increased amounts of Ca2+ are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by Generic Digiter - Digoxin. This is a different mechanism from that of catecholamines. Generic Digiter - Digoxin also increases vagal activity via its central action on the central nervous system, thus decreasing the conduction of electrical impulses through the AV node. This is important for its clinical use in different arrhythmias.
Active Ingredients: Digoxin
Inactive Ingredients: corn starch, croscarmellose sodium, microcrystalline cellulose, pregela-tinized starch, lactose monohydrate and anhydrous lactose, silicon dioxide

Generic Digiter - Digoxin used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Generic Digiter - Digoxin comes as a tablet, capsule, or pediatric elixir (liquid) to take by mouth. Digoxin is usually taken once a day. It is important that you always take the same brand of digoxin. Different brands of Generic Digiter - Digoxin have different amounts of active drug and your dose would need to be changed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take digoxin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Generic Digiter - Digoxin helps control your condition but will not cure it. Continue to take Generic Digiter - Digoxin even if you feel well. Do not stop taking Generic Digiter - Digoxin without talking to your doctor.
STORAGE
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Before taking Generic Digiter - Digoxin tell your doctor and pharmacist if you are allergic to Generic Digiter - Digoxin or any other drugs.
Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antacids, antibiotics, calcium, corticosteroids, diuretics (“water pills”), other medications for heart disease, thyroid medications, and vitamins.
Tell your doctor if you have or have ever had thyroid problems, heart arrhythmias, cancer, or kidney disease.
Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking digoxin, call your doctor. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking digoxin.
You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. Remember that alcohol can add to the drowsiness caused by this drug.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of overdose, call your local poison control center and if the victim has collapsed or is not breathing, call local emergency services.

Generic Digiter - Digoxin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
• dizziness or lightheadedness
• drowsiness
• vision changes (blurred or yellow)
• rash
• irregular heartbeat

If you experience any of the following symptoms, call your doctor immediately:
• upset stomach
• vomiting
• diarrhea
• loss of appetite
• swelling of the feet or hands
• unusual weight gain
• difficulty breathing

• acarbose
• agents used to treat cancer
• alprazolam, diazepam
• amphotericin B
• antacids
• barbiturate medicines for inducing sleep or treating seizures (convulsions)
• beta blockers, often used for high blood pressure or heart problems
• calcium, magnesium, or potassium salts
• captopril
• certain medicines used to decrease cholesterol (cholestyramine, colestipol, atorvastatin, fluvastatin, simvastatin)
• clarithromycin or erythromycin
• cyclosporine
• diet pills (stimulants) or drugs used to control weight
• diltiazem
• entecavir
• felodipine
• gatifloxacin
• herbal products such as flaxseed, ginger, ginseng, hawthorn, St. John's wort
• hormones such as prednisone or cortisone
• ndomethacin
• medicine for colds and breathing difficulties
• medicines to control heart rhythm (dofetilide, amiodarone, sotalol, and others)
• metformin
• neomycin
• omeprazole
• phenytoin
• psyllium
• quinine
• rabeprazole
• rifampin
• sevelamer
• sodium polystyrene sulfonate
• spironolactone
• St. John's wort
• succinylcholine
• sulfasalazine
• tetracycline antibiotics (doxycycline, tetracycline)
• thyroid hormones
• tramadol
• trimethoprim
• verapamil
• water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
Generic Digiter - Digoxin has potentially dangerous interaction with verapamil, amiodarone and erythromycin.

Keep all appointments with your doctor and the laboratory. Your doctor will need to determine your response to digoxin. You may have electrocardiograms (EKGs) and blood tests periodically, and your dose may need to be adjusted. Your doctor may ask you to check your pulse (heart rate). Ask your pharmacist or doctor to teach you how to take your pulse. If your pulse is faster or slower than it should be, call your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.